BIOCOMPATIBLE, SUBSTANCE-SPECIFIC REAGENTS FOR TREATING PHYSIOLOGICAL FLUIDS

摘要

The preparation and method of use of biocompatible water-insoluble reagents for removal of substances form physiological fluids is described. The reagent, comprising a carrier substrate with a layer of immobilized binding agent and biocompatibility agent, is produced by contacting an activated carrier substrate concomitantly or sequentially with binding agent and biocompatibility agent. The biocompatibility agent, which comprises an organic molecule with a nucleophilic moiety and a negatively-charged moiety separated by a spacer arm, reacts with the substrate surface through its nucleophilic moiety. The reagent may be incorporated in conventional extracorporeal systems for hemo- or plasmaperfusion to remove substances such as low-density lipoprotein.