| 摘要 |
<p>Methods for detecting the presence of selected mutations, such as the Thr-601 mutation and the Phe-355 mutation, in the plasminogen of a patient are disclosed. The methods include exposing amplified genomic DNA to a restriction endonuclease capable of differentially cleaving mutant and wild-type plasminogen DNA sequences, and analyzing the exposed DNA to detect the presence or absence of cleavage fragments diagnostic for the selected mutation. Diagnostic kits for the rapid detection of the selected mutation are also disclosed.</p> |
