| 摘要 |
The invention is a compound of R or S enantiomers or racemic mixtures of compounds of the formula: <CHEM> wherein: (A) X is (i) C1-C24 (ii) C1-C24 alkoxy; (iii) C1-C24 carboamoyloxy; (iiii) <CHEM> wherein n is an integer from 1 to 25 and m is an integer from 0 to 24 and the sum of n and m is less than or equal to 25; (v) phenyl; (vi) mono- or polysubstituted phenyl substituted with C1-C20 alkyl, C1-C20 alkoxy, halogen, trifluoromethyl, phenyl, substituted phenyl or benzyloxy; (vii) phenoxy; (viii) mono- or polysubstituted phenoxy substituted with C1-C20 alkyl, C1-C20 alkoxy, halogen, trifluoromethyl, phenyl substituted phenyl or benzyloxy; (ix) naphthaloxy; (x) mono- or polysubstituted naphthaloxy substituted with C1-C20 alkyl, C1-C20 alkoxy or halogen; (xi) -O-(CH2)r-O-((CH2)pO)t-(CH2)a-W wherein W is methyl or phenyl optionally substituted with C1-C3 alkyl, C1-C3 alkoxy or phenyl, r, p, t and a are integers such that the expression r+(p+1)t+a is also an integer and has a value of 3 to 20; r is greater than or equal to 2; p is greater than or equal to 2; t is greater than or equal to zero; and a is greater than or equal to zero; (B) i is an integer from 1 to 3 and j is an integer from 1 to 6; (C) Q is -OR2, <CHEM> or O-C-R2, wherein R2 is hydrogen, C1-C6 alkyl or C1-C6 alkenyl; (D) Y is a divalent radical -O- @-, -OCH2-, or <CHEM> (E) the moiety R3 represents one or more C1-C5 alkyl, C1-C5 alkoxy or halogen substituents of the aromatic ring; (F) the moiety -CH2A may be in the ortho, meta or para position wherein A is (i) a 5-7 member aromatic heterocyclic ring containing at least one nitrogen and one or more nitrogen or sulfur atoms: (ii) <CHEM> (iii) <CHEM> which are PAF inhibitors. 2 |
