发明名称 |
COMPOSITION AND METHOD FOR ACCELERATION OF CLOT LYSIS |
摘要 |
Blood clots and myocardial infarction can be treated by administering a hapten-binding molecule capable of preventing inhibition of plasmin by endogenous alpha-2-antiplasmin. The hapten-binding molecule may be co-administered with a thrombolytic agent capable of either dissolving fibrin-platelet clots or inhibiting their formation. This leads to increased clot lysis while minimizing fibrinogen breakdown and preventing the reocclusion of the affected coronary artery, even in the absence of heparin and when the concentration of thrombolytic agent is lower than that required by other potential therapies. |
申请公布号 |
ZA8902464(B) |
申请公布日期 |
1989.12.27 |
申请号 |
ZA19890002464 |
申请日期 |
1989.04.04 |
申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
GUY L. REED;GARY MATSUEDA;EDGAR HABER |
分类号 |
C12P21/08;A61K38/00;A61K38/46;A61K38/49;A61K39/395;A61K45/06;A61P7/02;A61P9/08;A61P9/10;C07K16/38;C07K16/40;C12N15/02;C12R1/91 |
主分类号 |
C12P21/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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