METHOD FOR CONTROLLING HIV INFECTIVITY AND VACCINES FOR USE THEREIN

摘要

A method and vaccine are provided for controlling infectivity of human immunodeficiency virus type 1 (HIV-1). The method and vaccine are predicated on the discovery that HIV-1 gp160 and gp120 contain one or more epitopes generating HIV-1 infection-enhancing antibodies (IEA). The method and vaccine of this invention use a polypeptide fragment or fragments of the total amino acid sequence of gp160 which includes at least one epitope of gp120 generating neutralizing antibodies to HIV-1 while being devoid of any epitope of gp160 generating IEA.