PRODUCTION OF ISOXAZOLE-4-CARBOXYLIC ACID AND HERBICIDE CONTAINING SAME

摘要

PURPOSE:To obtain isoxazole-4-carboxylic acid in high efficiency using microorganisms by putting to culture, in a culture medium, isoxazole-4- carboxylic acid-productive bacteria classified as Streptomyces. CONSTITUTION:Isoxazole-4-carboxylic acid-productive bacteria classified as Streptomyces is put to culture in a culture medium followed by isolating isoxazole-4-carboxylic acid from the resultant cultured product, thus obtaining the objective isoxazole-4-carboxylic acid. Said bacteria is e.g. Streptomyces sp HS-1 strain (FERM No.10011). The culture is pref. made under aerobic conditions, esp. using a depth culture method. The collection of the objective isoxazole-4-carboxylic acid should be carried out by adsorption or partition column chromatography, gel filtration method or dialysis.