Tripeptide renin inhibitors with N-terminal carbamoyl or acyl groups.

摘要

Tripeptide enzyme inhibitors of the formula: <CHEM> which have N-terminal carbamoyl or acyl functional groups and analogs thereof, which inhibit renin and are useful for treating various forms of renin-associated hypertension and congestive heart failure; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension or congestive heart failure or of establishing renin as a causative factor in these problems which employ the novel tripeptides.