摘要 |
The invention relates to quinazoline derivatives which possess anti-tumour activity; to processes for their manufacture; and to pharmaceutical compositions containing them. The invention provides a quinazoline of the formula:- <CHEM> wherein R<1> is hydrogen or amino, or alkyl or alkoxy each of up to 6 carbon atoms; or R<1> is substituted alkyl or alkoxy each of up to 3 carbon atoms; R<2> is hydrogen, alkyl, alkenyl, alkynyl, hydroxyalkyl or halogenoalkyl each of up to 6 carbon atoms; Ar is phenylene or heterocyclene; L is a group of the formula -CO.NH- or CO.NR<3>-, wherein R<3> is alkyl of up to 6 carbon atoms; and Y is hydrogen or alkyl, cylcoalkyl, alkenyl or alkynyl each of up to 6 carbon atoms; or Y is a group of the formula -A-Y<1> in which A is alkylene of up to 6 carbon atoms and Y<1> includes hydroxy, amino and cyano, and alkoxy, alkylamino and alkylthio each of up to 6 carbon atoms. |