发明名称 |
3-PROPENYLCEPHEM DERIVATIVE, PREPARATION THEREOF, CHEMICAL INTERMEDIATES THEREIN, PHARMACEUTICAL COMPOSITION AND USE |
摘要 |
A 3-propenylcephem derivative of the following formula: <CHEM> wherein R1 represents a fluoro-substituted lower alkyl group or a cyano-substituted lower alkyl group, and A represents a cyclic or an acylic ammonio group, or a pharmaceutically acceptable salt thereof, exhibiting excellent anti-bacterial activities against both Gram-positive bacteria and Gram-negative bacteria; Process for the preparation thereof; Anti-bacterial composition; Intermediate for the 3-propenylcehem derivative; and Process for the preparation of the intermediate. |
申请公布号 |
EP0264091(A3) |
申请公布日期 |
1989.12.27 |
申请号 |
EP19870114843 |
申请日期 |
1987.10.12 |
申请人 |
EISAI CO., LTD. |
发明人 |
KAMIYA, TAKASHI;NAITO, TOSHIHIKO;NEGI, SHIGETO;KOMATU, YUUKI;KAI, YASUNOBU;NAKAMURA, TAKAHARU;SUGIYAMA, ISAO;MACHIDA, YOSHIMASA;NOMOTO, SEIICHIRO;KITOH, KYOSUKE;KATSU, KANEMASA;YAMAUCHI, HIROSHI |
分类号 |
C07D501/46;A61K31/545;A61K31/546;C07D;C07D285/08;C07D501/00;C07D501/04;C07D501/24;C07D501/56;C07D519/00 |
主分类号 |
C07D501/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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