SULFONYLDECAHYDRO-8H-ISOQUINO-(2,1-G)(1,6)-NAPHTHYRIDINES,OPTICAL ISOMERS THEREOF AND RELATED COMPOUNDS

摘要

Compounds of the formula (I): in which: X and Y are independently hydrogen, hydroxy, lower alkyl, lower alkoxy or halo, or X and Y taken together is methylenedioxy or ethylene-1,2-dioxy, and R is lower alkyl, optionally substituted phenyl, -(CH2)mOR<1> or -NR<1>R<2>, wherein m is an integer of 1 to 6 and R<1> and R<2> are independently hydrogen or lower alkyl, or the group -NR<1>R<2> forms a heterocycle of the formula: wherein A is -CH2-, -NR<1>- or oxygen, wherein R<1> has the above meaning and the wavy lines indicate that the hydrogen atom attached thereto is in either the alpha - or beta -position; or a pharmaceutically acceptable salt thereof, are useful as selective alpha 2-blockers.