OSMOTIC CONTINUOUS DISPENSING ORAL DELIVERY SYSTEM CONTAINING A PHARMACEUTICALLY ACCEPTABLE ACTIVE AGENT HAVING IMPROVED CORE MEMBRANE ADHESION PROPERTIES

摘要

The present invention relates to an oral osmotic system for the control and continuous administration of metoprolol over a lengthy time interval, which contains a uniform, separate internal layer of water-soluble coating agent. Water-soluble coating agents which can be used are HPMC, PVP, optionally mixed with polyethylene glycol.