PROCESS FOR THE PREPARATION OF 1-PYRIDYL-ALKYL-4-ARYL PIPERAZINES WHICH ARE USEFUL AS ANTIHYPERTENSIVE COMPOUNDS, THEIR SEPARATION INTO THE RESPECTIVE OPTICAL ANTIPODES, AND THE STEREOISOMERIC COMPOUNDS SO OBTAINED

摘要

The present invention provides a process for the separation of the optical antipodes of the compound of the formula: (I) wherein P is ? , .beta. or .gamma. pyridyl, R is H; or CnH2n+1, n being a number from 1 to 4; and R' is H, halogen, CH3, OCH3 in which in process a) the racemic alcoholic derivative corresponding to the formula: (?)II is reacted with the chloride of the optically active acetylmandelic acid; b) the diastereoisomeric compound of the formula (+,L)III (-,D)III so obtained is hydrolyzed with hydroalcoholic KOH at room temperature; and when required c) the optically active alcoholic derivative of the formula (+)II (-)II so obtained after salification with alkaline hydrides or hydroxides in a solvent medium is treated with alkylating agents.