| 发明名称 |
HUMAN NATURAL INHIBITOR OF COLLAGENASES |
| 摘要 |
This invention refers to the novel 184 amino acid sequence of a human natural inhibitor of collagenases (NIC) and its production. It also refers to novel DNA and RNA sequences, plasmids, transformed prokaryotic and eukaryotic cells, the production of NIC amino acid sequences with and without glycosylation, and compositions containing these novel NICs to treat diseases that incorporate collagenase-type metalloproteinases as part of the disease process. |
| 申请公布号 |
DE3666826(D1) |
申请公布日期 |
1989.12.14 |
| 申请号 |
DE19863666826 |
申请日期 |
1986.01.16 |
| 申请人 |
G.D. SEARLE & CO. |
发明人 |
GALLOWAY, WILLIAM ALAN;CLISSOLD, PATRICIA MARY;MCCULLAGH, KEITH GRAHAM |
| 分类号 |
C12N15/09;A61K38/00;A61K38/55;A61P43/00;C07H21/02;C07K14/005;C07K14/195;C07K14/81;C12N1/00;C12N5/10;C12N9/99;C12N15/81;C12P21/00;C12R1/19;C12R1/865;C12R1/91;(IPC1-7):C07K13/00;C12N15/00;C07H21/04;C12P21/02;A61K37/02;A61K37/64 |
主分类号 |
C12N15/09 |
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