VERFAHREN ZUR HERSTELLUNG VON 3-(((2-(DIAMINOMETHYLEN)AMINO)-4-THIAZOLYL)METHYL)THIO-N-SULFAMOYLPROPIONAMIDIN

摘要

3-[[[2-(diaminomethylene)amino]-4-thiazolyl]methyl]thio-N-sulphamoyl propionamidine is prepared by reacting a mono-protected sulphamide with an alkyl 3-[[[2-(diaminomethylene)amino]-4-thiazolyl]methyl]thio-propionimidate, e.g. in an aprotic solvent, to produce a 3-[[[-2-(diaminomethylene)amino-4-thiazolyl]methyl]thio-N- (mono-protected sulphamoyl) propionamidine, with a subsequently deprotected, the protecting group being trialkylsilyl.