A PRECURSOR OF A C-TERMINAL AMIDATED PEPTIDE AND PRODUCTION THEREOF

摘要

A precursor of a C-terminal amidated peptide represented by the general formula P-X-Gly-Yn, wherein P is a peptide residue, X is an amino acid residue the C terminal of which (on the Gly side) can be converted in vivo to a -CONH2 group, Gly is a glycine residue, Y is a basic amino acid residue, n is an interger of 2 to 4 and a further amino acid residue other than Y or a peptide residue may be attached to Yn, is produced by a gene engineering technology. The precursor exhibits in vivo physiological activity like the C-terminal amidated peptide.