| 摘要 |
Compounds are disclosed of formula (I) <CHEM> wherein R1 represents -COR4, -CO2R4 or -COCO2R4 (where R4 represents a hydrogen atom or an unsubstituted or substituted C1-10 hydrocarbon moiety); R2 and R3 are the same or different and are C1-6alkyl or C3-6alkenyl; or -NR2R3 forms of 5-membered (optionally containing an oxygen atom adjacent to the nitrogen) or 6-membered ring, which ring optionally contains one unit of unsaturation and which is unsubstituted or substituted by optionally substituted methylidene, -COR5 (where R5 represents C1-6alkyl, -OR6 or -NHR6 and R6 represents hydrogen, C1-6alkyl, aryl, or ar(C1-6) alkyl), or =NOR7 (where R7 represents C1-6alkyl); X represents a direct bond, -CH2- or -CH2O-; Ar represents a substituted phenyl moiety; and physiologically acceptable salts thereof. The compounds are indicated as useful in the treatment of pain and cerebral ischaemia. Processes and intermediates for their preparation and pharmaceutical compositions containing them are also disclosed. |
