发明名称 |
BLOOD SUBSTITUTE |
摘要 |
A blood substitute suitable for replacing blood in mammalian subjects when performance of surgical procedures at hypothermic temperatures is described. The blood substitute comprises water, electrolytes at physiological concentration, dextran 40 at a concentration sufficient for the blood substitute to achieve a colloidal suspension having a fluid osmotic pressure essentially equivalent to mammalian plasma, HEPES buffer at a physiological pH, dextrose, magnesium ion at a concentration of about 0.01 M and potassium ion at a concentration greater than 10 mEq per liter sufficient to prevent or arrest cardiac fibrillation. In one embodiment the blood substitute is a multi-solution system wherein the solutions comprise differing levels of the above-indicated components and are administered sequentially to completely replace a subject's circulating blood. |
申请公布号 |
WO8910746(A3) |
申请公布日期 |
1989.12.14 |
申请号 |
WO1989US01761 |
申请日期 |
1989.04.26 |
申请人 |
CRYOMEDICAL SCIENCES INC. |
发明人 |
SEGALL, PAUL, E.;WAITZ, HAROLD, D.;STERNBERG, HAL |
分类号 |
A61K31/715;A61K9/00;A61K33/00;A61K33/06;A61K33/14;A61P7/08;A61P9/06 |
主分类号 |
A61K31/715 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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