发明名称 |
Mouse monoclonal antibodies to HIV-1P24 and their use in diagnostic tests. |
摘要 |
<p>The present invention provides monoclonal antibodies demonstrating specific reactivity with HIV-I p24. One monoclonal antibody designated 31-42-19 recognizes an unique epitope on HIV-I p24 that is not immunogenic in humans. 31-42-19 also reacts with an antigenically cross reactive epitope on HIV-2 p24. Another monoclonal antibody designated 31-90-25 recognizes an epitope within a highly immunogenic region of HIV-I p24. The present invention also provides cell lines capable of producing these monoclonal antibodies. The invention also includes a highly sensitive enzyme immunoassay for the detection of HIV-I p24 in biological fluids, using a monoclonal antibody mixture. The present invention further provides methods for the use of these monoclonal antibodies for the detection of anti-HIV-I p24 antibodies and HIV-2 p24 antigen in biological samples.</p> |
申请公布号 |
EP0345461(A2) |
申请公布日期 |
1989.12.13 |
申请号 |
EP19890108001 |
申请日期 |
1989.05.03 |
申请人 |
ABBOTT LABORATORIES |
发明人 |
MEHTA, SMRITI U.;HUNT, JEFFREY C.;DEVARE, SUSHIL G. |
分类号 |
G01N33/569;A61K39/395;C07K16/10;C12N5/20;C12P21/08;C12R1/91;G01N33/577 |
主分类号 |
G01N33/569 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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