发明名称 |
AMBLYOMMIN, A NEW ACTIVE SUBSTANCE FOR ANTICOAGULANT THERAPY |
摘要 |
The invention relates to a new active substance-amblyommin-for anticoagulant therapy and to a process for the isolation thereof from hard ticks. The isolated protein having a thrombin-inhibitory action has a molecular weight of 20000 to 30000 dalton, an isoelectric point between 5.05 and 5.65 and the partial amino acid sequences Ile-Leu-Phe-Thr-Gln-Gly-Asn-X-Gly-Glu-Leu-Glu-Asn-X-Phe-Glu-, Lys-Ile-Leu-Phe-X-Gln-Gly- and Ala-Ser-Tyr-Ile-Val-X-Ser-Glu-Ser-Ile-Gln-Ile-Leu-X-Leu-Ser-Glu-Gly-Ile- in which each radical X can be identical or different and each represents a naturally occurring amino acid. |
申请公布号 |
AU3595489(A) |
申请公布日期 |
1989.12.07 |
申请号 |
AU19890035954 |
申请日期 |
1989.06.01 |
申请人 |
HOECHST AKTIENGESELLSCHAFT |
发明人 |
WERNER BONIN;PAUL HABERMANN;DOMINIQUE TRIPIER;ELISABET WOHNER |
分类号 |
A61K38/55;A61K35/56;A61K38/00;A61P7/02;C07K1/14;C07K1/16;C07K14/00;C07K14/435;C07K14/44;C07K14/81 |
主分类号 |
A61K38/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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