| 摘要 |
The invention relates to a polypeptide of formula I:- R<1>-CO-A<1>-A<2>-A<3>-A<3>-A<4>-A<5>-A<6>-Q I wherein each of the generic terms is disclosed in full in the specification and includes:- R<1> is a 5- or 6-membered unsaturated heterocyclic ring which contains one, two or three nitrogen atoms, which ring may optionally bear one or two substituents; A<1> is a direct link to A<2>, or is His or D-His; A<2> is Trp or MeTrp; A<3> is Ala or MeAla; A<4> is Val; A<5> is Gly or D-Ala; A<6> is His or Lys(Z); and Q is a group of the formula -A<7>.R<2> in which A<7> is Leu or MeLeu and R<2> is hydroxy, amino, (1-3C)alkylamino or (1-3C)alkoxy; or Q is (1-6C)alkoxy or (1-10C)alkylamino. The compounds possess antagonist properties against bombesin-like peptides and are of value in the treatment of malignant disease in warm-blooded animals. |
