Method for the production of selegiline hydrochloride.

摘要

The present invention relates to a new method for preparing selegiline hydrochloride, particularly in the form of its (R)-(-)-enantiomer. Selegiline hydrochloride is a highly potent antiparkinsonic agent with low toxicity. The method of the invention consists in that 2-methylamino-1-phenylpropane is reacted with propargyl bromide and potassium carbonate, both in a molar excess of at least 10 %, based on the amount of 2-methylamino-1-phenylpropane, equivalent, with use of chloroform, methylene chloride, methanol or dimethylformamide as solvent, at a temperature within the range of from +5 DEG C to the boiling temperature of the reaction mixture; the formed base is converted into the hydrochloride using hydrogen chloride in isopropanol.