| 摘要 |
<p>NEW MATERIAL:A peptide expressed by the formula (X1 and X2 mean 0 or one optional amino acid residue, provided that X1 and X2 cannot be Phe at the same time). USE:A remedy for infectious diseases and cancers. PREPARATION:For example, styrene-1%-divinylbenzene polymer (PAM resin) having a phenylacetamidomethyl linker bonded thereto is used as a solid-phase carrier and tert-butyloxycarbonylated serine which is a C-terminal amino acid is then reacted therewith in the presence of a condensing agent to remove the amino protecting group. The above-mentioned operation is subsequently repeated according to an amino acid sequence of the peptide to synthesize a peptide chain on the carrier resin. Elimination of the peptide from the carrier resin and removal of the whole protecting groups are then carried out to afford the peptide expressed by the formula.</p> |
