| 摘要 |
This invention relates to a method of simultaneously determining DNA sequence variations at a large number of sites, and a kit suitable therefor. The method comprises an electrophoretic separation of restriction fragments in two dimensions on the basis of two independent criterions, namely, length and base pair sequence, and a detection of separated fragments by means of a labelled probe comprising one or more cores of repeat sequences. Preferred probes are GC-rich minisatellite or simple sequence core sequences. |
