发明名称 |
ANTI-IDIOTYPE ANTIBODIES TO ANTI-HUMAN HIGH MOLECULAR WEIGHT-MELANOMA ASSOCIATED ANTIGEN |
摘要 |
This invention discloses two novel anti-idiotypic antibodies, IMelpg1 and MF11-30 and equivalents thereof, as well as, antibody fragments, peptides or antisera capable of reacting with the idiotope of: (a) murine monoclonal antibody 225.28 and derivatives thereof; or with (b) any monoclonal antibody secreted by hybridomas from any species having the same immunological characteristics as antibody 225.28; or with (c) any polyclonal antisera from any species having the same immunological characteristics as antibody 225.28, capable of reacting with a specific determinant (epitope) of a high molecular weight-melanoma associated antigen are described, together with their preparation and use in the diagnosis, monitoring and treatment of tumors such as melanoma or other diseased cells which express the HMW-MAA epitope recognized by antibody 225.28. |
申请公布号 |
WO8911296(A1) |
申请公布日期 |
1989.11.30 |
申请号 |
WO1989US02073 |
申请日期 |
1989.05.17 |
申请人 |
FERRONE, SOLDANO;RAYCHAUDHURI, SYAMAL |
发明人 |
FERRONE, SOLDANO;RAYCHAUDHURI, SYAMAL |
分类号 |
G01N33/574;A61K39/00;A61K39/395;A61P35/00;C07K1/113;C07K1/22;C07K14/00;C07K16/00;C07K16/42;C07K19/00;C12N5/10;C12N15/02;C12P21/08;C12R1/91;G01N33/577;(IPC1-7):A61K39/395;C07K15/16;C12N15/00;G01N33/543 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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