| 摘要 |
A method for the delivery of therapeutic agents into the brain is disclosed. A selected chemical agent is first administered into the blood stream of a subject in order to increase blood brain barrier (BBB) permeability. Thereafter, a chemical conjugate consisting of a selected monoclonal antibody in combination with an enzyme is administered. The conjugate passes through the BBB and selectively binds to brain lesion/tumor tissue. The BBB is then allowed to return to ambient permeability levels, wherein residual circulating amounts of the conjugate in the subject are removed through renal or other clearance mechanisms. Next, a selected prodrug is administered having a molecular weight sufficiently small to pass through the BBB. The prodrug is reacted upon by the enzyme to form a therapeutic drug, such formation being directly at the site of the brain lesion/tumor proliferation. |
