发明名称 |
PROCESS FOR THE CONVERSION OF THE E-ISOMER OF 6-(SUBSTITUTED METHYLENE)-2-PENEMS INTO THE Z-ISOMER |
摘要 |
During the preparation of 6-(substituted methylene)-2-penem compounds (which are known for their antibacterial and beta -lactamase inhibitory properties) mixtures of the E-isomer and the Z-isomer may be formed. The Z-isomer is, however generally preferred, and the present invention provides a process whereby the E-isomer may be converted into the Z-isomer by reaction with an aromatic heterocyclic thiol in the presence of a base. |
申请公布号 |
ZA8803346(B) |
申请公布日期 |
1989.11.29 |
申请号 |
ZA19880003346 |
申请日期 |
1988.05.11 |
申请人 |
BEECHAM GROUP PLC |
发明人 |
NIGEL JOHN PERRYMAN BROOM |
分类号 |
C07D499/897;A61K31/43;A61P31/04;C07D499/04;C07D499/88 |
主分类号 |
C07D499/897 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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