| 摘要 |
10 Peptides of formula, e.g. (I)-(III) are new. - H-X-Ala-Ala-Ala-Asp-Thr-Gly-His-Ser-Asn-Gln-Val-Ser-Gln-Asn-Tyr-X-Z (I); - H-X-Ala-Ala-Ala-Asp-Thr-Gly-His-Ser-Ser-Gln-Val-Ser-Gln-Asn-Tyr-X-Z (II); and - H-X-Ala-Ala-Ala-Asp-Thr-Gly-Asn-Asn-Ser-Gln-Val-Ser-Glu-Asn-Tyr-X-Z (III) - (X is a chemical bond or a coupling-facilitating amino acid sequence; Z = NH2 or OH). - Also claimed is a method of discriminating between a false and true diagnosed HIV-1 positive serum sample, characterised in that at least one diagnostic antigen having the ability of binding to antibodies which have a binding affinity for cpds. contg. an amino acid sequence corresp. to an epitope or clusters of epitopes of HIV-1 p17, opt. coupled to a carrier, is added to the serum sample and that possible antigen/antibody complexes formed are detected using an immunoassay, whereby the discrimination is established based upon that the serum sample is false HIV-I positive if the complexes are detected and true HIV-1 positive if the complexes are not detected. |
