| 摘要 |
<p>The invention relates to a group of new 3,5-substituted 1,2,4-oxadizoles, and the prodrugs and salts thereof. The compounds are represented by the formula <CHEM> wherein -R is a phenyl group which may be substituted with 1-3 halogen atoms, alkyl groups or alkoxy groups (1-4 C), or with CF3, a group -O-(CH2)m-O- wherein m has the value 1 or 2; -X is the group (-CH=CH-)n, wherein n is 0 or 1; -R1 is hydrogen or alkyl having 1-4 C-atoms, and -R2 is a group -NR3R4, wherein R3 and R4 are saturated or unsaturated alkyl having 1-4 C-atoms; and the prodrugs and salts thereof with pharmacologically acceptable acids. It has been found that these compounds have interesting anti-convulsive activities, and are less toxic in comparison with related known compounds.</p> |
