VERFAHREN ZUR HERSTELLUNG EINER CHLORIERTEN, BROMIERTEN, RADIOBROMIERTEN, JODIERTEN UND/ODER RADIOJODIERTEN AROMATISCHEN ODER HETEROAROMATISCHEN VERBINDUNG, SOWIE EIN KIT ZUR HERSTELLUNG EINER AUF DIESE VERBINDUNG GEGRUENDETE DIAGNOSTISCHE ZUSAMMENSETZUNG.

摘要

The invention relates to a method of preparing a chlorinated, brominated, radiobrominated, iodinated and/or radio-iodinated aromatic or heteroaromatic compound, in which the (hetero)aromatic nucleus optionally comprises one or more additional substituents, by reacting the corresponding halogenated or diazonium-substituted compound in the presence of a water-soluble acid and of copper ions as a catalyst with a likewise water-soluble chloride, bromide radiobromide, iodide or radio-iodide, in which the reaction is carried out in the presence of one or more reduction agents, which are stable in acid medium, in a quantity exceeding the quantity of catalyst. The invention also relates to a composition suitable for diagnostic examination and to a kit for the preparation thereof. The invention further relates to a method and an equipment for the preparation of said composition.