Papillomavirus probes (HPV49, HPV50, HPV54, HPV55), products genetically and immunologically related to this papillomavirus and in vitro methods for the diagnosis of papillomavirus infections and for the production of antibodies against these papillomaviruses.

摘要

The invention relates to papillomavirus probes derived from new DNA-HPVs deposited at the CNCM on 6 May 1988 under the following filing numbers: - PGEM 4 HPV49 : I-754 - PSP 65 HPV50 : I-755 - PSP 64 HPV54 : I-756 - PGEM 4 HPV55A : I-757 - PGEM 4 HPV55B : I-758. These probes can be employed for in vitro detection: - in the case of HPV49 : of cutaneous or mucous verrucas (in particular ordinary and plantar verrucas) and of the differential diagnosis of verruci form epidermodysplasia - in the case of HPV50 : of verruciform epidermodysplasias, of inter-epithelial neoplasias and of cutaneous cancers - in the case of HPV55 : of genital neoplasias and of cancers of the neck of the uterus, - in the case of HPV55 : of genital neoplasias and of cancers of the neck of the uterus, of condylomas and of papillomas.