METHOD OF 4-DEMETHOXYANTHRACYCLINE DERIVATIVES PRODUCTION

摘要

Anthracycline glycosides of formula (I) and their pharmaceutically acceptable acid addn. salts are new where R1 = H or OH; one of R2 and R3 = H, the other is H or OH. Also new are the intermediates 4-demethoxy-4-amino -7-deoxy-daunomycinone (IX) and daunomycinones (II), opt. N-protected. - (I) is pref. 4-demethoxy-4 -amino-daunorubicin; 4-demethoxy- 4-amino-4'-epi-daunorubicin or 4-demethoxy-4-amino -4'-deoxy-daunorubicin, and the corresp. doxorubicin cpds.