摘要 |
Pharmaceutical compositions for treating hormone-dependent tumours without inducing hormonal castration contain a gonadoliberin derivative of general formula (I), Gip-His-Trp-Ser-Tyr-X1-X2-X3-Pro-X4 (I) wherein X1 stands for a glycyl group or a D-isomer of any native or synthetic aromatic D-amino acid group; X2 stands for an L-amino acid group bearing a C1-4alkyl or L-phenylalanyl or L-tryptophyl group; X3 stands for an L-amino-acid residue bearing a C1-4alkyl or C2-4alkanoyl amide side chain; and X4 means a glycyl amide or C1-4alkyl amide group, with the proviso that X3 means a group different from leucyl when X2 stands for a tryptophyl group and X1 is other than glycyl group, its addition salts formed with pharmaceutically acceptable acids or metal complexes. |