PROCESSO PARA A PREPARACAO DE DERIVADOS DE ALQUIL-CEFEM INSATURADOS EM POSICAO 3 A PARTIR DE NOVOS COMPOSTOS INTERMEDIOS DERIVADOS DE 3-TRIFLIL-CEFEM

摘要

There is disclosed a process for the production of certain 2-allyl-, and 3-butenyl-3-cephem derivatives by coupling a 3-chloromethyl-3-cephem with a hydrocarbyltributystannane in the presence of bis(dibenzylideneacetonyl)-palladium and a phosphine. The 3-allyl- and 3-butenyl-3-cephem derivatives so-produced are useful as broad-spectrum antibacterial agents.