| 摘要 |
<p>A cephem derivative represented by the following formula: <CHEM> wherein R1 means a fluorine-substituted lower alkyl and A1 denotes a cyclic or acyclic ammonio group, or a non-toxic salt thereof, is prepared by reacting a compound represented by the following formula: <CHEM> wherein A1 has the same meaning as defined above, with another compound represented by the following formula: <CHEM> wherein R1 has the same meaning as defined above, and if necessary, removing the protecting groups. The cephem compounds can be used for the manufacture of pharmaceutical compositions having antibacterial activity.</p> |
