Fluoroavermectin and fluoromilbemycin derivatives with antiparasitic and pesticidal properties.

摘要

Novel avermectin and milbemycin compounds, wherein at least one of the 4a, 5 or 4 sec positions are substituted with a fluoro groups, are prepared by replacement of hydroxy or other suitable leaving group of avermectin and milbemycin compounds with fluorine. The fluoroavermectin and fluoromilbemycin compounds have utility as anti-parasitic agents and as highly potent insecticides against agricultural pests.