DNA coding for thymosin and TNF.

摘要

Anti-tumor polypeptides represented by the amino acid sequence: (The amino acid sequence of TH beta 4)-Asp-Pro-x-(the amino acid sequence corresponding to the base sequence constructed by linking guanine with the beginning of the base sequence of the fourth exon of TNF- alpha ) wherein X is a part of the linkage or represents any of the following amino acid sequences: 1) Val-Ser-Ser-Ser-Arg-Thr-Pro-Ser-Asp-Lys-Pro-Val-Ala-His-Val-Val; 2) Val-Arg-Ser-Ser-Ser-Arg-Thr-Pro-Ser-Asp-Lys-Pro-Val-Ala-His-Val-Val; 3) Val-Lys-Ser-Cys-Thr-Arg-Thr-Pro-Ser-Arg-Lys-Pro-Val-Ala-His-Val-Val; 4) Val-Arg-Ser-Ser-Thr-Arg-Thr-Pro-Ser-Arg-Lys-Pro-Val-Ala-His-Val-Val; and 5) Val-Arg-Ser-Cys-Thr-Arg-Thr-Pro-Ser-Arg-Lys-Pro-Val-Ala-His-Val-Val. and, novel DNAs coding them, processes for their preparation, and anti-tumor agents comprising them are disclosed.