发明名称 |
Minimal derivatization of proteins. |
摘要 |
<p>There is disclosed a process for minimally derivatizing a targeting protein with a radionuclide such that the predominant species of derivatized targeting protein contains one radionuclide group as a single radiolabeled ligand, and whereby the binding characteristics of the targeting protein are minimally affected. There is further disclosed ligands that can chelate a metal radionuclide or bind a halogen radionuclide while providing a means for separating radiolabeled ligand from unradiolabeled ligand.</p> |
申请公布号 |
EP0339684(A2) |
申请公布日期 |
1989.11.02 |
申请号 |
EP19890107823 |
申请日期 |
1989.04.28 |
申请人 |
NEORX CORPORATION |
发明人 |
FRITZBERG, ALAN R.;WILBUR, DANIEL S.;SRINIVASAN, ANANTHACHARI;WESTER, DENNIS W. |
分类号 |
A61K51/10 |
主分类号 |
A61K51/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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