发明名称 4-Amino-3-acylquinoline derivatives, and their use as inhibitors of gastric secretion.
摘要 Compounds of structure (I): <CHEM> in which R<1> is hydrogen, C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6-alkyl, C3-6cycloalkyl, C3-6cycloalkylC1-6alkyl, phenyl, phenylC1-6alkyl, the phenyl groups being optionally substituted; R<2> is hydrogen, C1-6alkyl, C1-6alkoxy, amino C1-6alkylthio, halogen, cyano, hydroxy, carbamoyl, carboxy, C1-6alkanoyl or trifluoromethyl; m is 1 to 3; p is 0 to 4; R<3> is COR<4>; R<4> is hydroxy, C1-6alkoxy or NR<5>R<6>; R<5> and R<6> are each hydrogen or C1-6alkyl or together with the nitrogen atom to which they are attached form a heterocyclic ring; and R<7> is hydrogen, hydroxy, C1-6alkoxy or C1-6alkyl, processes for preparing them, intermediates useful in their preparation, pharmaceutical compositions containing them and their use in therapy as inhibitors for gastric acid secretions.
申请公布号 EP0339768(A1) 申请公布日期 1989.11.02
申请号 EP19890301805 申请日期 1989.02.23
申请人 SMITHKLINE BECKMAN INTERCREDIT B.V. 发明人 IFE, ROBERT JOHN;LEACH, COLIN ANDREW;BROWN, THOMAS HENRY
分类号 C07D215/54;A61K31/47;A61P1/04;C07D215/48 主分类号 C07D215/54
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