Aminoguanidine derivatives.

摘要

A aminoguanidine derivatives of the general formula: <CHEM> (wherein, R<1b> represents a hydrogen atom, alkyl group of from 1 to 6 carbon atom(s), cycloalkyl group of from 5 to 7 carbon atoms or carbocyclic or heterocyclic ring unsubstituted or substituted by from one to three halogen atom(s), alkyl group(s) of from 1 to 4 carbon atom(s), alkoxy group(s) of from 1 to 4 carbon atom(s) or nitro group, Xb represents a bond, alkylene group of from 1 to 4 carbon atom(s) or alkenylene group of from 2 to 4 carbon atoms, R<2b> represents a hydrogen atom, alkyl group of from 1 to 6 carbon atom(s) or phenyl group, R<3b> represents a hydrogen atom, phenyl group, alkyl group of from 1 to 4 carbon atom(s), phenylalkyl group of from 7 to 10 carbon atoms or pyridyl group <CHEM> represents a heterocyclic ring, which contains nitrogen atom or one nitrogen and one oxygen atom, of from 3 to 10 carbon atoms unsubstituted or substituted by a hydroxy group. With the proviso that the compounds wherein R<2b> represents a hydrogen atom, -Xb-R<1b> represents a hydrogen atom, methyl group, ethyl group or phenyl group and R<3b> represents a hydrogen atom or methyl group, are excluded.) or acid addition salt thereof possess inhibitory activity on Maillard reaciton, and therefore is useful for treating and/or prevention of several diabetic complications and diseases induced by aging.