| 摘要 |
<p>New amide compounds of the general formula [I]: <CHEM> wherein R is a hydrogen atom or an acyl group, m is an integer of 1 to 3, n is an integer of 1 to 4, p is an integer of 1 or 2, q is an integer of 1 to 6, x is an integer of 2 to 6 and y is an integer of 1 to 3, with the proviso that, when <CHEM> (ii) n is 1, (iii) p is 1, (iv) q is 5 and (v) R is hydrogen atom, [(CH2)x-NH]y is neither (CH2)2NH(CH2)3NH(CH2)3NH nor (CH2)2NH-(CH2)4NH(CH2)3NH, and salts thereof have excellent glutamate receptor-inhibiting activities, and they can be produced by the following reaction scheme: <CHEM> or <CHEM> wherein the symbols are as defined above except that the hydroxyl, imino or/and amino group or groups may be protected.</p> |
