PLASMINOGENE ACTIVATORS WITH INCREASED FIBRIN SELECTIVITY

摘要

A modified plasminogen activator having greater fibrin selectivity than the unmodified plasminogen activator from which it is derived is provided. The modified plasminogen activator includes at least one of the following domains: a kringle that is more homologous with a kringle of plasminogen than is any kringle of the umodified plasminogen activator; a first hybrid t-PA kringle, the first hybrid kringle being a fusion of a portion of t-PA kringle 1 and a portion of t-PA kringle 2; or a second hybrid t-PA kringle, the second hybrid kringle being a fusion of a portion of t-PA kringle 2 and a portion of an scu-PA kringle.