Method for production of 4-methyl-5-((2-aminoethyl)-thiomethyl)-imidazole.

摘要

4-Methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole can be effectively produced by the causing 4-methylimidazole or a salt thereof to react with (a) a formaldehyde adduct of cysteamine, (b) 2-aminoethanethiol sulphuric acid and formaldehyde or a formaldehyde oligomer, or (c) thiazolidine or a salt thereof, in the presence of a mineral acid. A portion of reaction liquid is withdrawn from the reaction system while maintaining the molar concentration of 4-methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole in the reaction system at a level not exceeding 70 mol% based on the total number of mols of 4-methylimidazole and 4-methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole. A liquid containing 4-methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole, is then separated from the reaction liquid and the remainder is recycled into the reaction system.