| 摘要 |
PURPOSE:To obtain the subject compound useful as a synthetic raw material for agricultural chemicals and medicines in high yield by reacting a gamma-haloacetic acid ester with a culture or fungal cells (treated substances) of a specific mold. CONSTITUTION:A gamma-haloacetic acid ester is reacted with a culture, fungal cells or their treated substance of a mold, belonging to the genus Cephalosporium, Paecilomyces, Verticillium, Fusarium, Ustilago or Gibberella [e.g., Cephalosporium charticola IFO 8952] and having the ability to convert the above-mentioned compound into a gamma-halo-beta-hydroxybutyric acid ester to afford the aimed compound. Furthermore, the culture is preferably normally carried out under aerobic conditions of pH3-8 and 10-40 deg.C for 1-10 days. |
