| 摘要 |
NEW MATERIAL:A compound expressed by formula I [Y represents C or N; R1 represents H or amino-protecting group; R2 represents H, formula II, etc.; R3 represents (protected) carboxyl or carboxylate; R4 represents bicyclic heteroring expressed by formula III (m is 1-3; n is 0-3; Q represents formula IV, etc.; B ring part represents 5 or 6 membered N-containing heterocyclic group optionally containing S atom, etc.; R5 represents alkyl optionally substituted with cyano, etc.)] and salt thereof. EXAMPLE:7beta-[2-(2-Aminothiazol-4-yl)-2-hydroxyiminoacetamide]-3-(6,7 -dihydro-5H- pyrrolo[1,2-C]imidazol-7-yl)thio-3-cephem-4-calboxylic acid. USE:An antimicrobial agent and synthetic intermediate therefor. PREPARATION:A compound expressed by formula V (R31 represents substituted carboxyl) is condensed with a compound expressed by formula VI (R11 represents amino-protecting group; R21 is same as R2) to form a compound expressed by formula VII, which is esterified and then reacted with a compound expressed by the formula HS-R41 (R41 is same as R4). |
