HAEMOPHILUS INFLUENAZE TYPE B OXIDIZED POLYSACCHARIDE-OUTER MEMBRANE PROTEIN CONJUGATE VACCINE

摘要

Immunogenic conjugates of a 38,000 daltons or 40,000 daltons outer membrane protein of H. Influenzae type b and oxidized polyribosyl-ribitol-phosphate polysaccharide fragments of H. influenzae type b are disclosed. Vaccines containing the conjugates are disclosed as useful in immunizing against H. Influenzae type b caused disease. Methods for isolating and purifying the 38,000 daltons and 40,000 daltons outer membrane proteins and for preparing the oxidized polyribosyl-ribitol-phosphate polysaccharide fragments are also disclosed.