Liquid chromatograph-direct coupled mass spectrometer.

摘要

A liquid chromatograph-direct coupled mass spectrometer comprises a liquid chromatograph section, a mass spectrometer section and an interface section coupling the liquid chromatograph section with the mass spectrometer section. The interface section is provided with a first nebulizing means (8B) for nebulizing an eluate of a hydrophobic solvent containing a sample in solution introduced from the liquid chromatograph section through a capillary continuously into a vacuum or atmospheric pressure region. The first nebulizing means (8B) is further provided with a second nebulizing means (8A) for nebulizing a hydrophilic solvent and with a heating means (9) for heating the first and second nebulizing means (8B, 8A). The mass spectrometer exhibits a high separability and has no limit to selection of a mobile phase solvent and an ionization solvent.