PROCESS FOR THE SYNTHESIS OF 3-THIO-4-QUINOLENE DERIVATIVES AND INTERMEDIATE COMPOUNDS FOR USE THEREIN,AND THEIR USE AS MEDICAMENTS

摘要

A process to prepare compounds of formula I in which n = 0, 1 or 2 comprising the cyclisation of compounds of formula II in which n - 0, 1 or 2. The cyclisation may be effected in the presence of an organic or inorganic base or thermally at a temperature in the range 40-160 DEG C. Compounds of formula II and certain analogues thereof are disclosed as cardiovascular agents.