Polypeptides with type IV collagen activity

摘要

A composition which can bind heparin and promote cellular adhesion is provided which consists essentially of a polypeptide of the formula: met-phe-lys-lys-pro-thr-pro-ser-thr-leu-lys-ala-gly-glu-leu-arg, thr-ala-gly-ser-cys-leu-arg-lys-phe-ser-thr-met, asn-pro-leu-cys-pro-pro-gly-thr-lys-ile-leu, or mixtures thereof. Medical devices such as prosthetic implants, percutaneous devices, bandages and cell culture substrates coated with the polypeptide composition are also provided.