| 摘要 |
<p>An immuno-stimulating blood preparation, suitable for e.g. tumor therapy, is prepared by incubating a cell-containing blood sample, especially whole blood, taken from a specific individual, with a mitogen in vitro to produce a blood preparation designed to be re-administered to the same individual. The method comprises the further step of removing anti-bodies, which are specific for the mitogen used, from the blood sample before the incubation with the mitogen in vitro. The anti-bodies are preferably removed by contacting the blood sample with the corresponding mitogen or its active derivatives or active immobilized forms of the mitogen. Preferred mitogen such as SEA have a strong specificity for MHC II on accessory cells such as monocytes and/or B cells. A blood treatment kit for carrying out the method comprises at least one blood container having a blood sample inlet and a blood sample outlet, separation means provided in said outlet, and means for contacting said blood sample with at least one agent having mitogenic activity in the blood container. The separation means are preferably capable of separating the mitogen from the blood sample to make the treated blood sample substantially free from mitogenic activity.</p> |
