Peptide derivatives

摘要

Somatostatin polypeptides containing at least one radical of the formula (a), (b) or (c) <IMAGE> in which Y1 is hydrogen, Y2 is hydrogen or hydroxyl, f and g are, independently of one another, 0 or 1, X1 is hydrogen, X2 is hydrogen or an amino protective group, and X3 is C2-6-alkylene, where the free valency in the radical (a), (b) or (c) is linked to the N-terminal amino group of the peptide, and the physiologically acceptable ethers and physiologically hydrolysable and acceptable esters thereof when the peptide contains at least one radical of the formula (a) or (b), in free form or in the form of an acid addition salt or complex. Compounds of this type have valuable pharmaceutical properties, in particular inhibiting GH, gastric and pancreatic secretion.